不同类型的牛奶与抑郁和焦虑的关联:前性队列研究和门德尔随机化分析
Chunying Wu1, Yusheng Liu1, Yigui Lai1
1Department of Central Laboratory, People's Hospital of Yangjiang, Yangjiang, China.
Frontiers in nutrition
|December 20, 2024
概括
消费半脱脂牛奶可能会降低抑郁和焦虑的风险. 这项研究表明,牛奶类型可以在心理健康策略中发挥作用.
科学领域:
- 营养精神病学 营养精神病学
- 流行病学 流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 牛奶消费与抑郁症和焦虑症等精神健康障碍之间的关联尚未得到充分证实.
- 调查牛奶摄入量和心理健康结果的前性队列研究有限.
- 这项研究解决了关于牛奶类型及其对抑郁和焦虑的影响的证据需求.
研究的目的:
- 调查不同类型的牛奶与抑郁和焦虑的发病率之间的关系.
- 使用孟德尔随机化 (MR) 探索牛奶消费和心理健康之间的潜在因果关系.
主要方法:
- 在一个大规模的英国生物库队列 (n=357,568) 上使用了考克斯的比例危险模型来评估关联.
- 采用双样本的门德尔随机化 (MR) 分析,使用FinnGen研究数据推断因果关系.
- 在初级分析中调整了社会人口统计学,生活方式和健康因素.
主要成果:
- 半脱脂牛奶的消费与抑郁症 (HR=0.88) 和焦虑症 (HR=0.90) 的风险降低有关.
- 全奶油牛奶与焦虑有保护性关联 (HR=0.84),而其他牛奶类型与抑郁症风险增加有关 (HR=1.14).
- 核磁共振分析支持半脱脂牛奶对抑郁症 (OR=0.83) 和焦虑症 (OR=0.71) 的潜在因果保护作用.
结论:
- 消费半脱脂牛奶可能与患抑郁症和焦虑症的风险较低有关.
- 研究结果表明,饮食选择,特别是半脱脂牛奶摄入量,可能是心理健康促进策略的组成部分.
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