抗氧化剂屏障,氧化/化应激和过敏中的蛋白质糖化:从基础研究到临床实践
Grzegorz Biedrzycki1, Blanka Wolszczak-Biedrzycka2, Justyna Dorf3
1Hospital Pharmacy, Provincial Psychiatric Hospital, Olsztyn, Poland.
Frontiers in immunology
|December 20, 2024
概括
氧化应激和抗氧化系统受损会使喘等过敏症状恶化. 虽然氧化还原生物标志物显示出诊断的前景,但抗氧化剂并不能有效地减少过敏的严重程度或进展.
科学领域:
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
- 病理生理学 病理生理学
背景情况:
- 氧化/化压力与过敏性疾病的发病有关,包括喘,过敏性鼻炎,亚托皮炎和疹.
- 过敏状况的特点是氧化还原平衡和蛋白质糖化中发生的干扰.
- 酶和非酶抗氧化剂系统的损害增加了过敏患者细胞对氧化损伤的敏感性.
研究的目的:
- 在过敏患者中审查最新的关于氧化还原稳定性干扰和蛋白质糖化方面的文献.
- 探索反应性氧/物种在恶化喘症状中的作用.
- 评估氧化还原生物标志物的诊断潜力和抗氧化剂在管理过敏疾病中的有效性.
主要方法:
- 关于氧化应激,蛋白质糖化和过敏疾病的最新研究的文献综述.
- 对反应性氧/物种影响喘病理学的机制的分析.
- 关于抗氧化剂在过敏中治疗用途的现有证据的评估.
主要成果:
- 酶和非酶抗氧化剂系统在过敏条件下受到损害.
- 反应性氧/物种通过激活炎症媒介来恶化喘,导致支气管收缩,粘液过分分泌,毛细血管透性增加和细胞膜损伤.
- 雷多克斯生物标志物在过敏患者中显示出显著的诊断潜力.
结论:
- 氧化还原稳定和蛋白质糖化中的干扰是过敏性疾病发病的关键因素.
- 反应性氧/物种在调解过敏炎症和症状严重程度方面发挥着重要作用.
- 目前的证据不支持使用抗氧化剂来减少过敏症状严重程度或疾病进展,尽管氧化还原生物标志物可能有助于诊断.
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