促炎症和高胰岛素血症的饮食模式与特定的肠道微生物组特征有关:一个TwinsUK队列研究
Ni Shi1, Sushma Nepal1,2, Rachel Hoobler3
1Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Gut microbiome (Cambridge, England)
|December 20, 2024
概括
代谢饮食模式通过改变肠道细菌来影响慢性疾病风险. 与高胰岛素血症和炎症相关的特定微生物特征影响胰岛素抵抗.
科学领域:
- 肠道微生物组研究研究
- 代谢健康 代谢健康
- 饮食模式和慢性疾病
背景情况:
- 代谢饮食模式,如实证饮食高胰岛素血症指数 (EDIH) 和实证饮食炎症模式 (EDIP) 影响慢性疾病.
- 结肠微生物组在调解这些饮食影响中的作用尚不清楚.
研究的目的:
- 为了确定与EDIH和EDIP相关的微生物组概况.
- 检查这些与饮食模式相关的微生物组概况和循环生物标志物之间的关系.
- 预测和选由这些微生物形状和饮食模式影响的生物途径.
主要方法:
- 在TwinsUK队列中的1610名成年人便16SrRNA数据的横截面分析.
- 弹性净回归用于确定EDIH和EDIP的微生物组概况.
- 多变量调整的线性回归用于评估与循环生物标志物的关联.
- PICRUSt2用于预测微生物生物路径.
主要成果:
- 对于EDIH (32个属) 和EDIP (15个属) 的微生物组特征得分与更高的胰岛素和HOMA-IR相关.
- 六个属与两种饮食分数呈现一致的关联.
- 脂肪酸生物合成,糖酸降解和美瓦隆酸代谢的途径与胰岛素和炎症饮食有关.
结论:
- 影响胰岛素和炎症的饮食模式可能会调节肠道微生物的组成和功能.
- 肠道微生物组的这种调节可能会影响慢性疾病的风险.
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