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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Target Cell Response to Hormones01:22

Target Cell Response to Hormones

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Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
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相关实验视频

Updated: Jun 4, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

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甲状腺激素与受控衰减参数之间的相关性:一个基于人口的横截面研究.

Sumei Li1, Xingye Wu2, Jingming Yu2

  • 1Department of Endocrinology and Metabolism, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, 530022, People's Republic of China.

Diabetes, metabolic syndrome and obesity : targets and therapy
|December 20, 2024
PubMed
概括
此摘要是机器生成的。

甲状腺激素自由甲状腺素 (FT4) 和自由3,5,3'-triiodothyronine (FT3) 显示与控制衰减参数 (CAP) 具有显著的线性和非线性关系. 这些发现为管理肝硬化症提供了新的见解.

关键词:
控制的减弱参数 控制的减弱参数没有自由的3,5,3′-triiodothyronine.自由的甲状腺素是没有的.非酒精性脂肪性肝病是什么?甲状腺激素是甲状腺激素的一种.短暂的弹性图谱 短暂的弹性图谱

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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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相关实验视频

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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Published on: October 6, 2023

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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

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Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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科学领域:

  • 内分泌学 在内分泌学.
  • 肝病学 肝病学是一种肝病学.
  • 医学诊断 医学诊断 医学诊断

背景情况:

  • 肝硬化,一种以脂肪在肝脏积累为特征的疾病,是全球日益严重的健康问题.
  • 控制衰减参数 (CAP) 是一种用于评估肝脏脂肪含量的非侵入性方法.
  • 甲状腺激素在新陈代谢过程中起着至关重要的作用,可能会影响肝脏健康.

研究的目的:

  • 研究甲状腺激素水平与CAP测量之间的关系.
  • 探索甲状腺激素在肝硬化症的发展或进展中的作用.
  • 为脂肪肝疾病的新型预防和治疗策略提供见解.

主要方法:

  • 分析了2018年至2023年期间接受CAP诊断的3461名参与者的数据.
  • 使用多重线性回归,受限立方线 (RCS) 和值效应分析.
  • 评估了自由甲状腺素 (FT4),自由3,5,3'-triiodothyronine (FT3) 和CAP值之间的关联.

主要成果:

  • 在FT4和CAP (系数 -0.855) 之间观察到一个反向线性关系.
  • 在FT3和CAP之间发现了正线性相关性 (系数2.182).
  • 非线性关联和子组分析揭示了复杂的相互作用,特别是在严重的肝硬化症和跨性别.

结论:

  • 在FT4,FT3和CAP之间存在显著的线性和非线性关系.
  • 甲状腺激素水平可能会显著影响肝脏肥胖症.
  • 这些发现表明,肝硬化症管理的潜在治疗点.