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塞夫特里亚引起的红细胞凝结及其对红细胞参数的影响:一个病例报告

Petra Andrasic¹, Renata Zrinski Topic¹, Ivan Pavic^2,3

¹Department of Medical Biochemistry and Hematology, Children's Hospital Zagreb, Zagreb, Croatia.

Biochemia medica

|December 20, 2024

概括

塞夫特里亚克森抗生素可以引起免疫血液溶解性贫血,影响红细胞计数. 周围血液涂抹检查对于检测模仿聚氨酸的药物诱导抗体至关重要.

科学领域:

血液学血液学血液学
临床免疫学临床免疫学
药理学药理学是指药理学的学科.

背景情况:

塞夫特里亚克松是一种常见的抗生素.
药物诱导的免疫血液溶解性贫血 (DIIHA) 是一个已知的不良影响.
DIIHA可以呈现出改变的红细胞参数.

研究的目的:

描述 ceftriaxone 对儿科患者红细胞参数的影响.
为了突出诊断的挑战,在识别 ceftriaxone 诱导的抗体.
分享管理预分析问题的经验.

主要方法:

两名儿科患者的病例报告.
使用自动化血液学分析仪分析红细胞参数.
周围血液涂抹检查.
血清检测 (适用性有限).

主要成果:

塞夫特里亚克森的使用导致红细胞计数和血红素的减少,红细胞指数升高.
周围血液涂抹显示了红细胞聚氨酸.
药物诱导的抗体模仿了一个患者的冷凝固素和另一个患者的热凝固素.
自动分析仪提供了最初的异常结果,但涂抹检查是诊断的关键.

结论:

塞夫特里亚克松可以引起DIIHA,具有特征性的实验室发现,即使没有明显的临床症状.
周围血液涂抹检查对于诊断 ceftriaxone 诱导的聚氨酸是必不可少的.
及时的实验室检查和干预对于预防并发症至关重要.

关键词:

结合的结合是因为结合.塞夫特里亚克松是什么意思血液溶解性贫血是什么意思在分析前出现的错误.红细胞计数是指红细胞的计数.

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