在患有亚临床甲状腺功能低下症的患者中,levothyroxine治疗降低了内分泌和总胆固醇度
Tihana Serdar Hiršl1, Koraljka Đurić2, Marina Čeprnja3
1Synlab Croatia, Polyclinic for Medical Laboratory Diagnostics, Zagreb, Croatia.
Biochemia medica
|December 20, 2024
概括
亚临床甲状腺功能低下症 (SCH) 与更高水平的内皮功能障碍标志物,如内和不对称的二甲基氨酸 (ADMA) 有关. 在SCH患者中,Levothyroxine治疗显著降低了内分泌和胆固醇,可能有助于预防动脉样硬化.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 生物化学 生化学
背景情况:
- 亚临床甲状腺功能低下症 (SCH) 是心血管疾病的独立风险因素,与内皮功能障碍和动脉样硬化有关.
- 轻度SCH (TSH ≤10 mIU/L) 可能涉及内皮功能标志物的特定变化.
研究的目的:
- 调查Levothyroxine治疗对内皮功能障碍标志物的影响 (内皮素-1,不对称的二甲基氨酸 (ADMA) 和内皮) 在轻度SCH患者中.
- 为了评估Levothyroxine治疗后这些标记物的变化,以实现euthyroidism.
主要方法:
- 一项前性病例控制研究,涉及轻度SCH患者和健康对照.
- 在SCH患者的基线和6个月Levothyroxine治疗后测量内皮功能障碍标志物和其他生化标志物.
主要成果:
- 与对照组相比,SCH患者的ADMA,内分泌,低密度脂蛋白胆固醇 (LDL) 和非高密度脂蛋白胆固醇 (非HDL) 度较高.
- 在SCH患者中,Levothyroxine治疗导致内分泌和总胆固醇 (CHOL) 度显著下降.
结论:
- 轻度SCH与内分泌,ADMA,LDL和非HDL水平升高有关,表明内皮功能障碍和动脉样硬化风险增加.
- 利沃氨酸治疗在降低SCH患者的内分泌和胆固醇水平方面显示出潜在的益处,有助于预防动脉样硬化.
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