缺乏认可的药物损失与小体积间歇性输液的管理
Aamir S Dave1, Sumeet Jain1, Michele Graci1
1North Shore University Hospital, Manhasset, NY, USA.
Hospital pharmacy
|December 20, 2024
概括
实施新的输液输注指南显著减少了输液线中的残留药物,提高了药物输送效率,并可能防止抗生素剂量不足. 这解决了药物管理中的一个关键问题.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 提高质量 提高质量
背景情况:
- 间歇性静脉注射 (IV),特别是抗生素,通常涉及小体积稀释在50-100毫升.
- BD Alaris的输液组可以保留25毫升,导致潜在的低剂量 (高达50%的药物损失).
- 缺乏针对小量静脉注射的标准化政策,导致药物流失,并有治疗失败和抗菌素耐药性的风险.
研究的目的:
- 在两个病房 (ICU和非ICU) 试行小型间歇性IV输注的新指南.
- 评估新指南对药物管理完整性的影响.
- 确定干预措施是否减少了IV线中的药物残留量.
主要方法:
- 进行了一项观测质量改进倡议.
- 实施了针对小量间歇性静脉注射的新指南.
- 在静脉注射线,静脉注射袋和静脉注射瓶中的药物残留量发生率通过直接观察和调查来评估.
主要成果:
- 总共观察到203次静脉注射,其中86%是抗生素.
- 在实施指南后,空气探测器前的残留液体从85%降至27% (P < .001).
- 输液袋中的残留液体从59%降至7.6% (P < .001),而输液瓶中的残留液体从47%降至24% (P < .001).
结论:
- 实施的干预措施显著减少了IV线,IV袋和IV瓶中的残留液体.
- 这种残留体积的减少可能会在静脉注射期间最大限度地减少药物损失.
- 这些发现支持制定和实施明确的小量间歇性静脉注射政策,以加强药物输送.
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