用克洛扎治疗的精神分裂症住院患者的患病率和与过度唾液相关的因素:一项回顾性研究

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Chanunnat Kitsinthopchai¹, Siripun Kumpeera¹, Apiradee Sangngarm²

¹Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, Thailand.

Hospital pharmacy

|December 20, 2024

概括

过多的唾液流动会影响14.6%的接受克洛扎治疗的精神分裂症患者. 男性的风险可能较低,而电疗法 (ECT) 在这些患者中显著增加了过的风险.

科学领域:

精神病学是一个精神病学.
药理学药理学是指药理学的学科.
临床医学临床医学

背景情况:

过多的唾液或过度的唾液产生会对患者的福祉和生活质量产生负面影响.
克洛扎宾是治疗耐药精神分裂症的关键治疗方法,是已知的过多唾液的原因.
了解过多唾液的患病率和相关因素对于患者的管理至关重要.

研究的目的:

为了确定与克洛札治疗的精神分裂症患者的过多唾液的患病率.
为了确定与克洛扎诱导的过多唾液相关的患者特征和治疗因素.
为了告知临床监测策略的患者在克洛扎宾治疗.

主要方法:

使用住院病人的医疗记录进行回顾性队列研究.
纳入标准:在2020年6月1日至2020年12月31日期间诊断出精神分裂症并接受克洛扎治疗.
统计分析包括描述性统计和多重物流回归来确定风险因素.

主要成果:

在96名患者中,过的总体患病率为14.6%.
单独治疗克洛扎宾的患者患病率为19.51%,而组合治疗的患者患病率为10.91%.
电疗法 (ECT) 使用显著增加了过的风险 (调整后OR:5.40,P=.03);男性性别显示了降低风险的趋势.

结论:

过多的唾液会影响14.6%的精神分裂症住院患者接受克洛扎治疗.
在这个人群中,ECT是发展过多唾液的重要危险因素.
临床医生应考虑使用ECT在监测克洛扎治疗患者的过多唾液时.

关键词:

克洛扎类药物克洛扎类药物过多的唾液流动精神分裂症是一种精神分裂症.

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