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甲状腺自身抗体升高作为2型糖尿病中代谢功能障碍相关的脂肪肝疾病的危险因素
Wenchang Wu1,2, Ziyi Yang1,2, Owen Li1
1Medical College, Wuhan University of Science and Technology, Wuhan, China.
Frontiers in endocrinology
|December 20, 2024
概括
甲状腺过氧化酶抗体 (TPOAb) 和甲状腺蛋白抗体 (TgAb) 水平升高与2型糖尿病 (T2DM) 患者的代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有关. 这些抗体和TSH一起被确定为MAFLD发展的危险因素.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是2型糖尿病 (T2DM) 患者日益关注的问题.
- 在T2DM中甲状腺自身免疫和MAFLD之间的相互作用需要进一步研究.
研究的目的:
- 探索甲状腺过氧化酶抗体 (TPOAb) 和甲状腺蛋白抗体 (TgAb) 水平与T2DM患者的MAFLD之间的关联.
- 确定该人群中MAFLD的潜在风险因素,并提供预防和治疗的见解.
主要方法:
- 一组432名T2DM患者使用腹部超声波和诊断标准对MAFLD进行了评估.
- 使用相关性分析和多变量逻辑回归来评估甲状腺抗体,TSH和MAFLD患病率之间的关系.
- 患者根据肝纤维化风险分层使用FIB-4指数.
主要成果:
- 与非MAFLD患者相比,MAFLD患者在正常甲状腺功能下表现出更高的TSH,TgAb和TPOAb水平.
- 提升的TSH和TPOAb水平被确定为T2DM中MAFLD的显著风险因素.
- 甲状腺自身抗体的阳性与MAFLD的更高患病率有关,而抗体水平在肝纤维化风险组中显示出不同的模式.
结论:
- 提升的TSH,TgAb和TPOAb与T2DM患者的MAFLD有关,即使甲状腺功能正常.
- TSH和TPOAb是T2DM中MAFLD的确诊危险因素.
- 在纤维化风险组中观察到的TgAb和TPOAb水平模式表明它们在MAFLD进展中的潜在作用.
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