相关实验视频

Updated: Jun 4, 2025

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

免疫遗传学和移植后事件在移植中的新方面

Ilkka Helanterä¹, Salla Markkinen², Jukka Partanen²

¹Transplantation and Liver Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Transplant international : official journal of the European Society for Organ Transplantation

|December 20, 2024

概括

对于脏移植的组织组织相容性的进展超出了HLA类型的范围. 全基因组匹配显示,通过考虑更广泛的遗传因素,有望减少移植拒绝.

科学领域:

免疫遗传学免疫遗传学
移植科学移植科学
基因组学就是基因组学.

背景情况:

人类白细胞抗原 (HLA) 类型对移植至关重要,但只捕获有限的遗传变异.
分子匹配越来越多地取代了传统的HLA匹配方法.
研究正在扩大,以确定影响移植结果的HLA位点以外的遗传因素.

研究的目的:

审查免疫遗传学和用于移植的组织组织相容性的最新进展.
突出了超越HLA.的全基因组遗传匹配的潜力.
讨论临床移植基因研究的挑战和未来方向.

主要方法:

对候选基因分析和全基因组关联研究 (GWAS) 的审查.
基因和遗传变异的全基因组匹配的探索.
对研究血液造血干细胞和移植中的遗传因素的分析.

主要成果:

分子HLA匹配正在取代血清学方法.
全基因组匹配方法在移植中显示出希望.
特定的基因变异,如LIMS1或CFH中的同卵性缺失,与急性排斥风险有关.

结论:

遗传组织兼容性评估正在发展到超越HLA.
更广泛的基因匹配策略为改善移植成功提供了潜力.
大规模的合作研究对于验证移植中的遗传发现至关重要.

关键词:

在 HLA 匹配的测试中.候选基因分析的研究结果全基因组关联研究研究.腎臟移植腎臟移植多基因风险评分多基因风险评分.

更多相关视频

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

相关概念视频

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...