自发性流产与FTO基因和食类胡卜素的相互作用;一个病例对照研究
Arezoo Amjadi1, Khadijeh Abbasi Mobarakeh2, Saeid Doaei3,4
1Department of Nutrition, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Journal of nutritional science
|December 20, 2024
概括
饮食中摄入β-密素可以保护具有特定FTO基因变异的妇女免受自发流产 (SA). 这一发现突出了营养和遗传学在怀孕结果之间的相互作用.
科学领域:
- 生殖健康 生殖健康
- 营养科学 营养科学
- 人类遗传学 人类遗传学
背景情况:
- 自发流产 (SA) 是一个常见的不良妊娠结果.
- 母亲的营养状况和遗传因素都与SA有关.
- 特定的食类胡卜素和FTO基因变异在SA中的作用需要进一步研究.
研究的目的:
- 调查饮食中的胡卜素摄入量与自发流产 (SA) 之间的关联.
- 为了检查FTO基因rs9939609多态化的影响,卡洛和SA之间的关系.
- 识别与遗传易感性相关的潜在的SA防护性饮食因素.
主要方法:
- 病例控制研究涉及192名SA妇女 (病例) 和347名健康妇女 (对照).
- 通过168项食物频率问卷 (FFQ) 评估饮食中的胡卜素摄入量.
- FTO基因rs9939609多态性基因组型采用四级原始ARMS-PCR.
主要成果:
- 在携带FTO rs9939609多态的TT基因型 (调整后β = -0.28,P = 0.02) 的携带者中,观察到beta-cryptoxanthin摄入量与SA风险之间存在显著的负相关性.
- 在不同FTO基因型中,SA和饮食摄入的β-胡卜素,α-胡卜素,黄蛋白或烯之间没有发现显著的关联.
- 似乎FTO基因型改变了胡卜素摄入量与SA风险之间的关联.
结论:
- 饮食中的β-密素可能会对自发流产产生保护作用,特别是在具有FTO rs9939609多态的TT基因型的个体中.
- 这表明基因与饮食的相互作用影响了SA风险.
- 需要进一步的研究来阐明这种保护作用背后的机制.
关键词:
ARMS-PCR,放大耐火突变系统-聚合酶链.抗氧化剂是一种抗氧化剂.胡卜素是一种胡卜素.FFQ,食物频率调查问卷这就是FTO基因.FTO,脂肪量和与肥胖相关的肥胖.氧化应激是一种氧化应激.SA, 自发流产 自发流产自发流产是一种自发的流产.世卫组织,世界卫生组织.更多相关视频
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