T细胞调节肠道运动,并塑造肠道神经元对肠道微生物群的反应
Patricia Rodrigues Marques de Souza1,2, Catherine M Keenan2,3,4, Laurie E Wallace2,3,4
1Department of Health Education, Federal University of Sergipe, Aracaju, SE, Brazil.
Gut microbes
|December 20, 2024
概括
肠道微生物群和T细胞影响肠道运动和神经发育. 细胞因子IL-1β和IL-17A通过微生物驱动的神经发生,而不是运动.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 肠道平衡依赖于肠道微生物群,免疫系统和肠道神经系统 (ENS).
- 它们相互作用的确切机制尚不清楚.
研究的目的:
- 研究肠道微生物群和T细胞如何调节肠道运输,肠道神经发生和神经元密度.
- 阐明细胞因子IL-1β和IL-17A在这些过程中的作用.
主要方法:
- 野生类型和T细胞缺乏的无菌小鼠的比较,这些小鼠被特定无病原体 (SPF) 微生物群,传统上培养的SPF或细分丝状细菌 (SFB) 所定居.
- 评估小肠道过渡,肠道神经元密度,神经发生标志物 (Sox2,nestin),免疫细胞群 (Th17,Treg) 和细胞因子水平 (IL-1β,IL-17A).
- 使用IL-1β和IL-17A中和的干预.
主要成果:
- 在T细胞依赖的方式上,SPF微生物群增加了小肠道运输.
- SPF和SFB微生物群都增加了神经元密度,并刺激了肠道神经发生,T细胞依赖性因肠道区域而异.
- SPF殖民增加了Th17细胞和Treg细胞,同时增加了IL-1β和IL-17A水平.
- 对IL-1β和IL-17A的中和影响了微生物介导的神经发生,但没有影响运动.
结论:
- 肠道微生物群和T细胞通过复杂的相互作用协调肠道生理.
- 特定的细胞因子IL-1β和IL-17A是微生物群诱导的肠道神经发生的关键媒介.
- 这些发现为控制肠道功能的微生物群-神经免疫轴提供了新的见解.
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