在中年早期滥用酒精的病因和相关物质
Erin Lumpe1, Angela Pascale2, Mallory Stephenson2,3
1Department of Psychology, Rutgers University, New Brunswick, New Jersey, USA.
Alcohol, clinical & experimental research
|December 20, 2024
概括
中年早期的滥用酒精具有显著的遗传和环境影响,这些影响因性别而异. 尽管存在家庭因素,但滥用酒精与健康和人际关系等领域的功能不佳有关.
科学领域:
- 精神病学是一个精神病学.
- 行为遗传学 行为遗传学
- 公共卫生 公共卫生
背景情况:
- 中年早期 (30-40岁) 是人口变化和滥用酒精的关键时期.
- 这种发育阶段在酒精使用研究中没有得到充分的研究.
- 在中年早期了解滥用酒精对于长期的成年人福祉至关重要.
研究的目的:
- 为了检查早期中年期滥用酒精的遗传性.
- 调查酒精滥用与社会人口统计学,身体健康和福祉因素之间的关联.
- 为了确定这些关联在控制家族影响时是否存在,使用双胞胎对比.
主要方法:
- 利用了来自1446对芬兰双胞胎和748对非双胞胎 (平均年龄34岁) 的数据.
- 使用复合指数评估滥用酒精 (频率,中毒,重度插曲性饮酒,酒精问题).
- 用于遗传性的性别限制模型和个人和双胞胎分析的回归模型.
主要成果:
- 滥用酒精的遗传性因性别而异 (女性:62%的附加遗传,38%的独特环境;男性:49%的附加遗传,51%的独特环境).
- 较高的滥用酒精得分与较差的关系稳定性,财务状况,教育,自我评估健康,生活满意度和心理健康相关.
- 在大多数因素的双胞胎分析中,除了财务状况和教育,仍然存在显著的关联.
结论:
- 性差异存在于影响中年早期滥用酒精的病因因素中.
- 滥用酒精与多个领域的功能不佳有关,即使考虑到共同的家庭因素.
- 研究结果表明,滥用酒精可能导致中年早期到中年后期的功能下降.
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