在患有炎症性肠病的儿童中,无症状的Clostridioides difficile定居的患病率和后果
Seth A Reasoner1, Lisa S Zhang2, Rachel Bernard2
1Division of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
无症状的Clostridioides difficile殖民在儿科炎症性肠病 (IBD) 患者中很常见. 被殖民的儿童在以后患有C. difficile感染 (CDI) 的风险更高.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
- 微生物组研究 微生物组研究
背景情况:
- 艰难的克洛斯特里迪奥伊德殖民在儿科炎症性肠病 (IBD) 中很常见.
- 无症状的殖民使IBD管理和CDI诊断复杂化.
- 关于这一群体的殖民率,风险因素和结果的数据有限.
研究的目的:
- 调查IBD儿童无症状C. difficile殖民的患病率,风险因素和结果.
- 为了建立未来纵向研究的基线数据.
主要方法:
- 在没有急性胃肠道症状的87名IBD儿童的未来随访.
- 查C.困难菌的殖民化.
- 对风险因素的单变量回归分析.
- 追踪后续的C.困难感染 (CDI) 诊断.
主要成果:
- 13.8%的儿童 (12/87) 没有症状的C. difficile殖民.
- 升高的白细胞计数与殖民 (单变分析) 有关.
- 25% (3/12) 的被殖民儿童在90天内患有CDI,而非被殖民儿童的比例为0% (p=0.002).
结论:
- 无症状的C. difficile殖民在儿科IBD中很普遍.
- 殖民可能预测未来的CDI发展.
- 在儿科IBD中需要进一步对C. difficile进行纵向监测.
更多相关视频
09:12A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
12:58A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
