在接受teprotumumab治疗的老年甲状腺眼病患者中有效性,安全性和复发率
1Israel Englander Department of Ophthalmology, Weill Cornell Medical College, New York City, New York, U.S.A.
Ophthalmic plastic and reconstructive surgery
|December 20, 2024
概括
在老年成人患者中,teprotumumab有效地降低了甲状腺眼病活动和亡. 这表明对这一人口群体有潜在的益处,尽管不良事件需要监测.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 老年医学 老年医学
背景情况:
- 人口老龄化需要评估与年龄有关的疾病的治疗方法.
- 甲状腺眼病 (TED) 影响生活质量,特别是在老年人中.
- 在TED上,teprotumumab是有前途的,但在75岁以上的患者中数据有限.
研究的目的:
- 评估teprotumumab在78-86岁甲状腺眼病患者的疗效和安全性.
- 为了评估临床活动得分 (CAS) 的变化,双眼视,和proptosis.
- 在这个年龄较大的群体中记录不良事件.
主要方法:
- 四名女性患者 (78-86岁) 的回顾案例系列与TED.
- 患者接受了teprotumumab输注 (7-8个输注).
- 结果包括CAS,主观双眼视,proptosis (Hertel测量) 和不良事件.
主要成果:
- 所有患者都显示CAS降低.
- 两名患者在主观双眼视的情况有所改善.
- 所有测量眼睛 (n=6) 的proptosis减少≥2mm.
- 常见的不良事件:高血糖,失血症,疲劳,脱发.
- 一个糖尿病患者的A1C升高; 一个经历了疾病复发.
结论:
- 在TED的老年患者中,teprotumumab在降低疾病活性和亡方面表现出有效性.
- 虽然一般耐受良好,但建议对高血糖和潜在的复发进行仔细监测.
- 需要进一步的研究来证实这些发现在更大的老年人群中.
相关概念视频
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...