在70岁的没有认知障碍的个体中,生物学大脑年龄和弹性
Anna Marseglia1, Caroline Dartora1, Jessica Samuelsson2
1Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 20, 2024
概括
大脑年龄差距 (BAG) 是大脑弹性的标志物,与生活方式因素如体力活动和糖尿病和中风等健康状况有关. 这些因素影响老年人的大脑外观和认知功能.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 大脑年龄差距 (BAG) 作为大脑恢复力的生物标志物.
- 了解BAG与各种健康和生活方式因素的关联对于衰老中的认知健康至关重要.
研究的目的:
- 研究大脑年龄差距 (BAG) 与生活暴露,神经成像,生物过程和认知功能的关联.
- 探索生活方式和健康如何影响老年人的大脑外观和弹性.
主要方法:
- 通过将预测的大脑年龄从739名没有神经障碍的七十岁的年龄中减去预测的大脑年龄来得出的BAG.
- 利用强大的线性回归来评估与生命暴露,血生物标志物,MRI,CSF生物标志物和认知表现的关联.
主要成果:
- 更大的BAG (看起来老的大脑) 与身体不活动,糖尿病和中风相关.
- 身体活动减轻了肥胖和BAG之间的关联.
- 较高的BAG与增加的小血管疾病,白质变化,炎症,高葡萄糖和较差的血管相关认知有关.
结论:
- 与血管相关的生活方式选择和健康状况显著影响大脑的外观和弹性.
- 炎症和胰岛素调节是理解血管认知障碍的关键因素.
- 在BAG相关因素中观察到性别特异性差异.
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