血清炎症性细胞因子和脑衍生的神经营养因子之间的相互作用在第一发精神分裂症患者的认知功能
Li-Jun Cui1, Li-Li Cai2, Wan-Qiu Na2
1Key Laboratory of Psychiatry, Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, Huzhou 313000, Zhejiang Province, China.
第一发精神分裂症患者表现出与免疫系统失衡和下脑衍生神经营养因子 (BDNF) 相关的认知障碍. 这些因素,包括交白素-6和交白素-1β,显著影响认知功能,如注意力和记忆力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症认知障碍 (SCZ) 的发病原因尚不清楚.
- 炎症免疫失调和改变的大脑衍生神经变因子 (BDNF) 与SCZ精神病理学有关.
- 这些因素与第一期SCZ认知功能障碍之间的关联尚未得到充分研究.
研究的目的:
- 为了研究认知功能,炎症性细胞因子和BDNF之间的相互作用效应,在第一集SCZ患者中.
- 阐明特定的炎症标志物与认知缺陷之间的关系.
主要方法:
- 在84名第一期SCZ患者和80名健康对照人群中进行了横截面病例控制研究.
- 通过ELISA测量IL-1β,IL-4,IL-6,IL-10和BDNF的血清水平.
- 用中国简短认知测试 (C-BCT) 评估认知功能;用积极和消极综合征尺度评估精神症状.
主要成果:
- 与对照组相比,SCZ患者的IL-1β和IL-6水平较高,BDNF水平较低,C-BCT得分较差 (P<0.001).
- BDNF与IL-6负相关 (r = -0.324,P < 0.05).BDNF与IL-6负相关 (r = -0.324,P < 0.05).BDNF与IL-6负相关 (r = -0.324,P < 0.05).
- 认知领域 (信息处理,注意力,工作记忆,执行功能) 与IL-1β和IL-6负相关,与BDNF正相关 (所有P<0.05). IL-6,IL-1β和BDNF显著影响了C-BCT尺寸.
结论:
- 免疫功能障碍和神经营养缺陷之间的相互关系被认为是第一期SCZ认知障碍的基础.
- 炎症性细胞因子 (IL-1β,IL-6) 和BDNF在早期精神分裂症中观察到的认知缺陷中起着重要作用.
- 这些发现突出了SCZ认知功能障碍的潜在治疗点.
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