相关实验视频

Updated: Jun 4, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

双S通过诱导肠道微生物群失生症来降低卵细胞质量

Jiaming Zhang¹, Xiaoxia Yu¹, Weidong Li²

¹State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children, and Reproductive Health, Shandong University, Jinan, China.

|December 20, 2024

概括

双S (BPS) 暴露会破坏肠道细菌,导致炎症和卵子质量差. 酸寡糖化物可以通过恢复肠道健康来预防这些有害影响.

科学领域:

生殖生物学生殖生物学
环境毒理学环境毒理学
微生物组研究的研究.

背景情况:

卵细胞发育对环境因素很敏感.
双S (BPS) 是一种BPA的替代品,具有生殖毒性问题.
由BPS引起的卵细胞损伤的机制尚未完全理解.

研究的目的:

调查Bisphenol S (BPS) 如何影响卵细胞质量.
探索肠道微生物群在BPS诱导的生殖毒性中的作用.
确定潜在的预防策略来应对BPS的影响.

主要方法:

评估BPS暴露对肠道微生物群组成和功能的影响.
评估肠道透性和炎症标志物.
在BPS暴露和/或酸寡糖处理后检查卵细胞质量参数.

主要成果:

暴露于BPS会导致肠道微生物群失生症,增加肠道透性和炎症.
这些肠道变化导致卵细胞质量受损.
酸寡糖治疗恢复了肠道平衡,并保护卵细胞免受BPS损伤.

结论:

BPS通过诱导肠道失生症,肠道透性和炎症来降低卵细胞质量.
酸寡糖化物通过调节肠道微生物群,作为一个有希望的预防策略.
这项研究强调了肠-卵巢轴与环境生殖毒性的联系.

关键词:

酸的寡糖化物.双醇 S 是一种双醇.我们的肠道微生物群.卵子细胞卵子细胞

更多相关视频

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

相关概念视频

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...