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HPMCAS等级对从无形固体分散中释放弱基药物的影响

Pradnya Bapat1, Lynne S Taylor1

  • 1Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.

Molecular pharmaceutics
|December 20, 2024
PubMed
概括

弱基药物与基甲基纤维素酸盐酸盐 (HPMCAS) 之间的静电相互作用会影响无形固体分散 (ASD) 中的药物释放. 通过增加pH值来降低药物电离,改善了这些ASDs中的药物释放率.

关键词:
关键的离子化程度的程度.静电相互作用 静电相互作用它们的pH值为pH.溶解度 溶解度 溶解度 溶解度

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