冷却减少了0.09%的环素A溶液的灌注不适
William Ngo, Nijani Nagaarudkumaran1, Cassandra Bonnie Huynh2
1Centre for Ocular Research and Education, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.
概括
冷却局部环素A (CsA) 眼滴显著减少了 60% 的干眼患者的插入不适. 这种简单的方法可以改善对治疗干眼病的CSA治疗的坚持.
科学领域:
- 眼科医生 眼科 眼科
- 干眼疾病研究 干眼疾病研究
- 眼科治疗学 眼科治疗学
背景情况:
- 局部使用的环素A (CsA) 是干眼疾病的常见治疗方法.
- 用局部CSA灌注的不适可能会对患者的坚持产生负面影响.
- 研究改善患者对CSA的体验的方法至关重要.
研究的目的:
- 量化和比较与冷 (4°C) 与热 (23°C) 0.09% CsA眼滴相关的灌注不适.
- 评估温度对患者在CSA灌注过程中报告的不适感的影响.
主要方法:
- 一个随机的交叉研究,涉及40名干眼参与者.
- 参与者在一只眼睛里得到一滴冷CSA,在另一只眼睛里得到一滴温暖CSA.
- 在灌入后的10分钟内,不适感被评为0-10级;累积不适感是使用曲线下的面积来计算的.
主要成果:
- 60%的参与者报告说,与温暖相比,冷CSA减少了累积的不适.
- 在这个小组中,冷CsA灌注显示累积不适明显较低 (p<0.01).
- 在冷CSA灌注后立即观察到平均减少1个不适点的中位数.
结论:
- 制冷局部CsA眼滴可以显著减少大多数患者的插入不适.
- 冷CsA灌注可能会提高患者的舒适度,并可能改善对干眼治疗的坚持.
- 虽然一些患者更喜欢温暖的CSA,但与冷的相比,整体的不适感并没有显著不同.
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