结合抗生素对耐药性的影响:系统性审查和元分析
Berit Siedentop1,2, Viacheslav N Kachalov2,3, Christopher Witzany1
1Institute of Integrative Biology, Department of Environmental Systems Science, ETH Zürich, Zurich, Switzerland.
eLife
|December 20, 2024
概括
抗生素组合疗法是一种抗生素组合疗法.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 了解抗生素耐药性的演变至关重要.
- 组合治疗对耐药性的影响尚未完全理解.
- 这项研究调查了结合抗生素如何影响患者内耐药性的发展.
研究的目的:
- 分析抗生素联合治疗对细菌耐药性发展的影响.
- 探索组合疗法可能减缓抗性的条件.
- 评估各种细菌病原体和抗生素方案的耐药性发展.
主要方法:
- 对 (准) 随机对照试验 (RCT) 的系统审查和元分析.
- 在 2022 年 11 月 24 日之前搜索了 CENTRAL,EMBASE 和 PubMed 数据库.
- 包括比较不同数量的抗生素的试验;评估从基线到后续培养的耐药性获得.
主要成果:
- 确定了42个试验,其中29个 (5054名患者) 被纳入分析.
- 使用更多抗生素获得耐药性的概率比率是1.23 (95% CI 0.68-2.25),表明存在相当大的异质性 (I2=77%).
- 初步证据表明,根据病原体或疾病,组合疗法的潜在益处或危害.
结论:
- 关于组合治疗对抗性影响的RCT证据有限且不确.
- 目前的数据与有益和有害影响兼容.
- 需要进行进一步的强化试验和精心设计的观察性研究,以澄清组合疗法在抗药性发展中的作用.
关键词:
抗生素耐药性 抗生素耐药性组合疗法治疗组合治疗.人类 人类 人类 人类 人类 人类 人类传染病是一种传染性疾病.医学 医学 医学 医学 医学这是一个元分析.微生物学的微生物.电阻的演变是电阻的演变.系统性审查 系统性审查更多相关视频
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