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Updated: Jun 4, 2025

Protein Engineering by Yeast Surface Display
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Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

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以进化为基础的蛋白质工程:在transthyretins和5-hydroxyisourate hydrolases之间进行功能切换

Rafael Pereira Lemos1,2, Julia T Rodrigues1, Gabriel Portwood1

  • 1Laboratory for Macromolecular Biophysics - LBM, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Journal of biomolecular structure & dynamics
|December 20, 2024
PubMed
概括

研究人员通过改变跨甲基素 (TTR) 和5-基苏酸酶 (HIUase) 序列来设计新的酶. 这种以进化为基础的方法成功地创造了具有改变功能的活性酶,证明了残留物特定的工程能力.

关键词:
5-氧苏酸酸酶-5-氧苏酸转甲基素是一种转甲基素.分子建模分子建模蛋白质设计战略 蛋白质设计策略蛋白质工程工程 蛋白质工程蛋白质的进化 蛋白质的进化

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