药剂师领导的管理模式和慢性心力衰竭患者的药物坚持:一项随机临床试验
Lingjiao Wang1, Yuanyuan Zhao2,3, Liping Han4
1Department of Clinical Pharmacy, The First Hospital of Hebei Medical University, Hebei, China.
JAMA network open
|December 20, 2024
概括
一个由药剂师领导的管理模式改善了中国慢性心力衰竭 (CHF) 患者的药物坚持. 这种使用社交媒体的干预措施,在药物坚持方面表现出比常规护理的适度但显著的收益.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 数字健康数字健康
背景情况:
- 药物不良服药是慢性心力衰竭 (CHF) 管理的一个重要问题,导致发病率和死亡率增加,特别是在中国.
- 需要有效的策略来提高这种脆弱患者群体的坚持率.
研究的目的:
- 评估药剂师主导的管理模式,与社交媒体平台集成,对心血管疾病患者的药物坚持的影响.
- 将这种干预与随机临床试验环境中的常规护理进行比较.
主要方法:
- 一项前性的多中心随机临床试验,涉及中国445名心血管衰竭患者.
- 参与者被随机分配到一个由药剂师领导的干预组 (包括微信通信) 或常规护理对照组.
- 测量的主要结局是52周内药物覆盖日数 (PDC) 的比例.
主要成果:
- 干预组在52周内表现出心力衰竭药物的显著更高的PDC (8.1%的增加;P <.001).
- 与对照组相比,干预组中更大比例的患者实现了80%或更高的PDC (OR,0.34;P <.001).
结论:
- 药剂师主导的管理模式,结合社交媒体,为心血管疾病患者提供了适度但显著的药物坚持改善.
- 这种方法有望加强中国和潜在的其他地区的慢性疾病管理.
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