手握强度,步行节奏和遗传风险与发生性心律失常的关联
Panpan He1, Ziliang Ye, Mengyi Liu
1Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
较强的握手力和快速的步行节奏与降低患心律失常的风险有关,包括心房动 (AF). 这些保护作用在具有较低AF遗传倾向的个体中更为明显.
科学领域:
- 心血管健康 心血管健康
- 运动生理学 运动生理学
- 遗传学 遗传学 是一个
背景情况:
- 节律失常,如心房动 (AF),心室节律失常和肌节律失常,对健康构成重大风险.
- 身体力量和步行节奏等生活方式因素可能会影响心律失常的发展.
- 遗传倾向也在发生心律失常的风险中起作用.
研究的目的:
- 为了研究握手力,步行节奏和主要心律失常的发生率之间的关联.
- 探索生活方式因素 (握手力,步行节奏) 与与心律失常发育有关的遗传风险之间的相互作用.
主要方法:
- 一项前性队列研究,利用英国生物银行487,673名参与者的数据.
- 使用动力表测量手握强度;自报告的步行速度.
- 考克斯比例危险模型用于分析与发生性AF,心室失常症和胸失常症的关联,平均随访时间为12.4年.
主要成果:
- 与手握强度低的手握强度相比,正常的手握强度与发生性AF,心室节律失常和肌节律失常的风险较低有关.
- 快速的步行节奏与较慢的步行节奏相比,显著与所有研究的心律失常的风险降低有关.
- 手握力和步行节奏与AF的反向关联在具有AF遗传风险较低的个体中更为明显.
结论:
- 手握强度和步行速度与心律失常的发生率相反相关.
- 保持良好的身体力量和快速的步行节奏可能有助于预防心律失常.
- 改变生活方式对那些对心房的遗传易感性较低的人来说可能特别有益.
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