在COVID-19感染和接种疫苗后,血管结合组织疾病中的心血管并发症
Anthony L Guerrerio1, Allyson Mateja2, Gretchen MacCarrick3
1Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
PloS one
|December 20, 2024
概括
患有Marfan综合征等结合组织疾病的个人在COVID-19感染后没有增加心脏事件,除了可能的心律失常. 在这个人群中,COVID-19疫苗接种没有增加心血管事件.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 感染和接种疫苗可能会增加心血管疾病 (CVE) 的风险.
- 患有血管连接组织疾病 (VCTD) 的个人,如马凡综合征 (MFS),洛伊斯-迪茨综合征 (LDS) 和血管埃勒斯-丹洛斯综合征 (vEDS) 可能会增加脆弱性.
研究的目的:
- 调查COVID-19感染或接种疫苗后患有MFS,LDS或vEDS的患者中CVE的风险.
- 评估COVID-19疫苗接种在患有VCTD的个体中的安全性.
主要方法:
- 一项基于网络的横截面调查收集了325名受访者的自我报告数据.
- 数据包括COVID-19疾病/接种疫苗史,CVE发生率和接种疫苗后不良事件.
- 考克斯的比例危险模型分析了COVID-19暴露和CVE在30-90天内之间的关联.
主要成果:
- COVID-19疾病与感染后30天内新出现异常心律的比率更高有关.
- 在COVID-19疾病后90天内没有观察到其他CVEs.
- 在接种任何一剂COVID-19疫苗后的30天内,没有检测到增加的CVE率.
结论:
- 在患有MFS,LDS或vEDS的个体中,COVID-19疾病并没有显著增加CVEs,心律失常可能是例外.
- 疫苗接种后CVE没有大幅增加,这支持了对有资格接种VCTD患者的COVID-19疫苗的建议.
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