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基于ROS的生物材料的进展,用于传感神经听力损失治疗

Baoying Xu¹, Yuqi Huang¹, Dehong Yu¹

¹Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, China.

|December 20, 2024

概括

活性氧物种 (ROS) 引起的氧化应激会损害听觉系统,导致神经传感器听力损失 (SNHL). 清除ROS的生物材料提供了一种有前途的纳米医学方法,通过中和这些有害分子来治疗SNHL.

科学领域:

生物材料科学生物材料科学
耳鼻喉科耳鼻喉科耳鼻喉科
纳米医学是一种纳米医学.

背景情况:

感官神经听力损失 (SNHL) 是一个重要的全球健康问题.
由活性氧物种 (ROS) 驱动的氧化应激是SNHL的关键病理机制.
ROS会诱导耳毛细胞的损伤和亡,导致无法逆转的听力损伤.

研究的目的:

系统地审查SNHL中ROS介导的氧化应激机制.
探索ROS-scavenging生物材料对SNHL的治疗潜力.
评估这些生物材料在临床应用中的翻译潜力和挑战.

主要方法:

在SNHL中对ROS介导的氧化应激进行了全面的文献综述.
分析病因因素,包括衰老,声学创伤和耳毒性.
评估ROS清除生物材料的设计,功能和治疗应用.

主要成果:

通过细胞损伤和亡,ROS在SNHL病原发生中发挥着关键作用.
清除ROS的生物材料显示出作为向抗氧化纳米药物的潜力.
最近的进展表明,基于生物材料的SNHL治疗方式具有前景.

结论:

减少ROS的生物材料是SNHL管理的一个有前途的战略.
需要进一步的研究和开发来将这些生物材料纳入临床实践.
这些生物材料具有革命性的潜力,可以彻底改变SNHL治疗.

关键词:

氧化应激是一种氧化应激.在ROS-scavenging生物材料中使用.反应性氧物种 (ROS) 是一种反应性氧物种.感官神经神经听力损失是什么

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相关概念视频

Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.