内脏脂肪是COVID-19死亡率的主要断层风险因素
Luis Ricardo Hinojosa-Gutiérrez1, Adriana Lizbeth González-Sánchez1, Jair Antonio Rios-Muñoz1
1Radiology Physician, Radiology Departament, Unidad Medica de Alta Especialidad, Hospital de Especialidades No 1, Centro Médico Nacional del Bajío, Boulevard Adolfo López Mateos esquina Insurgentes S/N, Colonia Los Paraísos, CP 37260, León, Guanajuato, Mexico.
Heart & lung : the journal of critical care
|December 20, 2024
概括
高的内脏脂肪是COVID-19死亡率的重要预测因素. 这项研究发现,通过断层扫描测量的内脏脂肪增加与COVID-19肺炎患者的死亡有很强的相关性.
科学领域:
- 医疗成像医学成像
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 肥胖是已知的COVID-19死亡风险因素,高BMI增加死亡风险.
- 之前的研究探讨了内脏脂肪和严重的COVID-19,但没有与死亡率的直接联系.
- 对内脏脂肪的断层定量提供了预测COVID-19结果的潜在标记.
研究的目的:
- 为了确定断层扫描的发现,特别是内脏脂肪,区分COVID-19肺炎患者,死于幸存者.
- 用胸部CT扫描来调查内脏脂肪和COVID-19死亡率之间的关联.
主要方法:
- 一个病例控制研究 (1:1比) 涉及429名来自墨西哥三级医院的COVID-19肺炎患者.
- 数据包括胸部计算机断层扫描 (CT) 扫描,分析诸如肺部参与和内脏脂肪等变量.
- 多变量分析计算了几率比率,以确定死亡率的断层预测因素.
主要成果:
- 内脏脂肪显示,在COVID-19肺炎患者中,死亡率的显著几率比 (OR) 为8.79.
- 其他断层扫描变量,包括肺部卷入和病变模式,在统计学上与死亡率无关.
- 该研究分析了213名已故患者和216名幸存者的数据.
结论:
- 通过断层扫描量化的内脏脂肪成为COVID-19肺炎死亡率的最重要的断层扫描风险因素.
- 这些发现强调了评估COVID-19患者内脏脂肪的风险分层的重要性.
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