用多种方法对瑞典子群体和混合物风险评估进行了扩展的PFAS分析
Josefin A Engelhardt1, Merle M Plassmann1, Jana M Weiss1
1Department of Environmental Science, Stockholm University, Stockholm, Sweden.
Environment international
|December 20, 2024
概括
和多基基物质 (PFAS) 是广泛存在的环境污染物. 这项研究发现,瑞典人口中63%的人因暴露于PFAS而表现出不良健康影响的风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 人类健康 人类健康 人类健康
背景情况:
- 和多基基物质 (PFAS) 是全球检测到的污染物.
- 之前的研究发现PFAS是人类血液中化学混合物的显著风险驱动因素.
- 人们对广泛暴露于PFAS对健康的影响存在担忧.
研究的目的:
- 为了确定瑞典亚群中的PFAS暴露水平.
- 调查与这种暴露相关的潜在健康风险.
- 评估混合物风险评估 (MRA) 策略对健康结果评估的有效性.
主要方法:
- 分析了来自60名斯德哥尔摩献血者的人体血清样本.
- 一种目标方法量化了32个PFAS分析物和270多个可疑特征.
- 应用了9个MRA策略,使用衍生和确定的效果水平.
主要成果:
- 二十六种PFAS被定量,七种可疑的PFAS特征被半定量.
- 整个受研究的人群都超过了一些风险值,这表明可能出现高胆固醇和免疫抑制.
- 使用高确定性人类生物监测指导值,MRA表明63%的个人面临不良健康影响的风险.
结论:
- 在瑞典一般人口中暴露于PFAS是令人担忧的.
- 这项研究提供了关于人类血液中H-PFCAs半量化的新数据.
- 这些发现凸显了对PFAS暴露的持续监测和风险评估的需要.
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