环境温度对人口血压的直接和尿液电解质介导的影响:因果调解分析
Ayesha Mukhopadhyay1, Momenul Haque Mondol2, Mahbubur Rahman3
1Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, TN, USA.
Environment international
|December 20, 2024
概括
高的环境热量直接显著降低血压 (BP). 尿液电解质在调解这种热引起的血压降低方面起到很小的作用,需要对潜在机制进行进一步的研究.
科学领域:
- 环境健康 环境健康
- 心血管生理学心血管生理学
- 流行病学 流行病学
背景情况:
- 环境温度升高可以通过血管扩张等直接的生理反应影响血压 (BP).
- 对血压的间接影响可能通过尿体积和电解质平衡的改变而发生.
- 了解这些途径对于公共卫生至关重要,特别是在高热度暴露的地区.
研究的目的:
- 评估环境温度对血压的直接和尿液电解质介导的影响.
- 量化特定尿液电解质 (,,,,) 对这种关系的影响.
主要方法:
- 在孟加拉国 (2016年12月至2017年5月) 随机对照试验中利用了5,624人访问的数据.
- 将参与者BP和尿液电解质数据与当地环境温度记录联系起来.
- 采用因果调解分析,使用线性混合模型评估直接和间接影响.
主要成果:
- 每日温度增加5°C与缩血压直接降低-1.42 mmHg有关.
- 通过尿液电解质介导的影响是最小的: (-0.12 mmHg), (0.15 mmHg), (0.06 mmHg) 和 (-0.00 mmHg).
- 同样的反向关联也被观察到对透静血压,脉冲压和平均动脉压.
结论:
- 环境热量对血压有着显著的,主要是直接的,反向的影响.
- 通过尿液电解质 (,,,,) 介导的间接影响是最小的.
- 需要进一步的研究来阐明与热有关的BP变化的机制和临床影响.
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