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Updated: Jun 4, 2025

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions
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在癌细胞中的动态蛋白质凝聚物中,LncRNAs负责监护

Jiaojiao Hu1, Dan Li2, Cong Liu1

  • 1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

Molecular cell
|December 20, 2024
PubMed
概括

长非编码RNA DNAJC3-AS1 调节癌细胞中的纤维拉林凝结. 这种促进凝聚和防止聚合的双重作用为癌症治疗提供了针对 lncRNAs 的新治疗策略.

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The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
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