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Updated: Jun 4, 2025

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
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Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

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人类翻译启动的定量分析揭示了有力调节内源性和治疗修饰mRNAs的元素

Cole J T Lewis1, Li H Xie2, Shivani Milind Bhandarkar1

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA.

Molecular cell
|December 20, 2024
PubMed
概括

研究人员开发了一种高通量方法来测量治疗信使RNA (mRNA) 的翻译启动. 这种技术可以识别出显著提高蛋白质生产的序列,从而改善mRNA疗法和疫苗.

关键词:
5′未翻译的区域这是一种N1-甲基pseudouridine.基因组RNA的修饰是RNA的修饰.高通量选的高通量选核糖体的核糖体是指核糖体中的核糖体.治疗性的mRNA.开始翻译 开始翻译

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