口腔微生物群签名作为胃癌风险评估的潜在生物标志物
Haejin In1, Shruthi R Perati2, Mykhaylo Usyk3
1Division of Surgical Oncology, Rutgers Cancer Institute, New Brunswick, NJ; Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
概括
口腔微生物组分析揭示了胃癌 (GC) 和前恶性胃病 (Pre-GC) 患者的细菌特征. 这些口腔微生物概况可以帮助区分健康个体和面临GC风险的个体.
科学领域:
- 微生物组研究的研究.
- 癌症诊断 癌症诊断 癌症诊断
- 口腔健康 口腔健康
背景情况:
- 胃癌 (GC) 是一个重要的全球健康问题,排名为癌症相关死亡的第五大原因.
- 研究口腔微生物群为区分GC,前恶性胃病 (Pre-GC) 和健康对照提供了潜在的途径.
研究的目的:
- 分析口腔微生物组的生物多样性和组成在GC,Pre-GC和控制参与者.
- 识别特定的口腔微生物特征,可以区分这些群体.
- 评估口腔微生物组资料的诊断潜力,以预测GC风险.
主要方法:
- 从98名参与者 (30名GC,30名Pre-GC,38名对照) 收集口水样本.
- 提取DNA,测序,并对口腔微生物群的生物多样性和组成进行全面分析.
- 利用接收器操作特征 (ROC) 曲线来评估已识别的微生物特征的辨别力.
主要成果:
- 在GC和对照组之间观察到口腔微生物组β多样性的显著差异 (p<0.02).
- 32个细菌系在GC与对照中差异丰富,23个在Pre-GC与对照中差异丰富.
- 基于关键细菌特征的模型准确地区分了GC和对照 (AUC=0.880) 和Pre-GC和对照 (AUC=0.943).
结论:
- 在GC和Pre-GC参与者的口腔微生物组概况与对照组不同,尽管彼此相似.
- 这些独特的口腔微生物特征对胃癌风险的非侵入性预测具有前途.
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