怀孕前空气污染暴露与幼儿生长轨迹的关联:一项前性队列研究
Jiawen Liao1, Weili Yan2, Yi Zhang2
1Department of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Environmental research
|December 20, 2024
概括
孕前暴露于空气污染,包括PM2.5和PM10,与儿童肥胖风险增加有关. 怀孕前的三个月是影响孩子体重轨迹的关键窗口.
科学领域:
- 环境健康 环境健康
- 儿科 儿科 儿科
- 流行病学 流行病学
背景情况:
- 孕期暴露于空气污染与儿童肥胖有关.
- 在怀孕前期空气污染对儿童发育的影响仍未得到充分研究.
- 怀孕前阶段是环境暴露影响生长和肥胖风险的关键窗口.
研究的目的:
- 调查空气污染暴露在怀孕前对儿童体重和BMI增长轨迹的影响.
- 为了确定空气污染暴露的关键时间窗口.
- 评估特定空气污染物 (PM2.5,PM10,NO2) 与儿童成长结果之间的关联.
主要方法:
- 基于人口的前性队列研究在中国上海.
- 包括怀孕前的妇女和他们的孩子被跟踪到2岁.
- 使用时空模型估计空气污染暴露 (PM2.5,PM10,NO2) 并定期评估儿童体重和BMI.
- 应用多变量和纵向模型 (零碎线性混合效应) 来分析生长轨迹.
主要成果:
- 孕前增加的PM2.5暴露与2岁时更高的BMIZ相关.
- 孕前增加的PM10暴露与2岁时更高的BMI相关.
- 更高的体重,BMI和BMIZ增长率与预先的NO2和PM暴露有关.
- 特定的子组 (男性,年轻的母亲,超重/肥胖的母亲) 显示出更大的易感性.
结论:
- 三个月的预孕期是空气污染暴露影响儿童体重的关键窗口.
- 对空气污染的暴露有助于儿童肥胖风险.
- 进一步的研究和公共卫生干预措施是有必要的,以减轻这些风险.
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