功能,功能衰退和腹腔大动脉动脉瘤的风险:斯德哥尔摩CREAtinine测量 (SCREAM) 项目
Shigeru Tanaka1, Alessandro Bosi2, Edouard L Fu3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
概括
较低的估计膜过率 (eGFR) 和更快的eGFR下降与腹腔大动脉瘤 (AAA) 的风险增加有关. 这包括更高的致命AAA的机会,特别是严重的慢性病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管外科 血管外科
- 流行病学 流行病学
背景情况:
- 低估计的淋巴膜过率 (eGFR) 是动脉疾病的已知危险因素.
- 需要进一步调查eGFR与腹腔大动脉瘤 (AAA) 风险之间的关联.
研究的目的:
- 检查eGFR,年度eGFR下降和发展AAA的风险之间的关系.
- 评估完整和破裂的AAA以及致命的AAA的风险.
主要方法:
- 使用2011-2021年斯德哥尔摩医疗记录进行的观察性研究.
- 对人口统计和临床因素进行调整的考克斯回归分析.
- 在常规肌素检测中包括在基线没有AAA的参与者.
主要成果:
- 较低的eGFR水平与AAA风险增加有关;例如,eGFR 15mL/min/1.73m2显示AAA的HR为1.49和致命AAA的HR为3.73.
- 较快的eGFR下降与较高的AAA事件率相关,下降>3mL/分钟/年显示HR 1.46.
- 对于完整和破裂的AAA,结果一致,在具有较低EGFR或更快下降的个体中,致命AAA的发生率显著更高.
结论:
- 单个eGFR测量和更快的eGFR下降率都与AAA风险独立相关.
- 患有慢性病严重程度或加速EGFR下降的人面临AAA的风险增加,尤其是致命的结果.
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