TRPA1有助于烟草气溶引起的呼吸抑制
Sichong Chen1, Nobuaki Takahashi2, Momoka Okahara3
1Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan; Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, China.
过渡性受体潜能安基林-1 (TRPA1) 通过呼吸系统抑郁介导了对烟草烟雾的急性保护. 然而,TRPA1并不能防止重复暴露的肺炎,也不能影响对烟草气溶的行为反应.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 暂时受体潜在基林-1 (TRPA1) 是鼻腔中刺激化学物质的传感器,触发保护性呼吸反应.
- TRPA1在调解对烟草烟雾的反应中的作用仍然不清楚,烟草烟雾是一种复杂的刺激物混合物.
研究的目的:
- 研究TRPA1对烟草烟雾气溶的呼吸和行为反应的贡献.
- 为了比较传统和加热烟草产品气溶对TRPA1介导反应和肺炎的影响.
主要方法:
- 在TRPA1条件淘汰小鼠和对照小鼠中对烟草烟雾气溶的呼吸和行为反应的比较.
- 对传统和加热烟草制品气溶的重复暴露后肺炎的评估.
主要成果:
- 完整的TRPA1小鼠对烟草烟雾气溶的反应表现出呼吸抑制,这与三角神经的激活有关.
- 对烟草烟雾气溶的行为反应 (避免或偏好) 独立于TRPA1.
- 不管 TRPA1 状态如何,重复暴露于烟草烟雾气溶引起的肺炎.
- 与传统烟草烟雾相比,加热烟草产品气溶显示TRPA1激活和炎症减少.
结论:
- 通过诱导呼吸抑制,TRPA1在对烟草烟雾的急性保护中发挥作用.
- 然而,TRPA1与重复暴露于烟草烟雾的肺炎的发展无关.
- 烟草烟雾气溶含有吸引小鼠的元素,独立于TRPA1.
- 加热的烟草产品气溶在激活TRPA1和引起炎症方面似乎不如传统烟草烟雾那么强大.
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