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开发含有阿克西替尼布的聚合物眼部植入物,用于治疗后眼部疾病

Febri Annuryanti¹, Masoud Adhami², Ubah Abdi²

¹School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom; Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia.

International journal of pharmaceutics

|December 20, 2024

概括

新的3D打印植入物为糖尿病视网膜病变 (DR) 和与年龄有关的黄斑变性 (AMD) 等视力威胁的疾病提供持续的药物输送,改善治疗选择.

科学领域:

眼科医生眼科眼科
生物材料科学生物材料科学
药物输送系统药物输送系统

背景情况:

糖尿病视网膜病变 (DR) 和与年龄相关的黄斑变性 (AMD) 是全球视力丧失的主要原因.
目前的静脉内抗VEGF治疗是有效的,但昂贵,需要频繁的管理.
药物释放植入物为持续的眼部药物输送提供了潜在的解决方案.

研究的目的:

开发和描述3D打印的植入物,用于持续释放VEGF受体抑制剂阿克西替尼 (AX).
评估这些新型眼部植入物的药物释放动力学和生物相容性.
探索Axitinib作为治疗后眼部疾病的治疗剂.

主要方法:

使用半固体挤出 (SSE) 3D打印与聚烯酸 (PCL) 和Precirol®制造阿克西替尼装载植入物.
使用FTIR,SEM和热分析进行表征.
用ARPE-19细胞进行体外药物释放研究和生物相容性测试.

主要成果:

成功制造出稳定的,不相互作用的AX载荷植入物.
药物释放跟随10%的AX负载和20%的AX负载的科尔斯迈耶-佩帕斯的第一阶段动力学.
装有AX的植入物表现出良好的生物相容性和对眼部应用的安全性.

结论:

3D打印的PCL/Precirol®植入物为持续的阿西替尼布输送提供了一个可行的平台.
这些植入物对治疗糖尿病视网膜病变和与年龄相关的黄斑变性有前途.
这项技术可以为频繁注射提供一个更方便和潜在的更安全的替代方案.

关键词:

3D打印技术是3D打印的一种技术.亚克西替尼布 (Axitinib) 是一种药物.眼部植入物可以用于眼部植入物.半固体挤出技术半固体挤出技术持续的药物释放持续的药物释放

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