二甲基粉和凝的水凝与组织粘合剂的潜在应用交叉连接
Yun Liu1, Haibo Zhao1, Yishan Fang1
1State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China; School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan, Shandong 250353, China.
International journal of biological macromolecules
|December 20, 2024
概括
一种新型的自我愈合水凝 (DS/Gel-CDH) 与蛋白质粘合剂相比,在伤口关闭方面表现出优越的粘合力. 这种生物相容和可注射的组织粘合剂有助于在没有毒性或炎症的情况下治愈.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 聚合物化学 聚合物化学
背景情况:
- 目前的手术静血和伤口关闭方法依赖于侵入性技术.
- 来自自然生物大分子的可注射水凝具有作为组织粘合剂的潜力,但在未经修改的生物分子特性方面面临挑战.
- 需要先进的生物材料,即可注射,粘合,自我愈合和生物相容的伤口管理.
研究的目的:
- 开发一种新型的自我愈合,可注射和粘合的水凝,用于组织修复.
- 评估开发的水凝的粘附强度,生物相容性和体内疗效.
- 通过创建一个多功能生物材料来解决当前组织粘合剂的局限性.
主要方法:
- 通过Schiff基交叉连接,在碳基化物修饰的凝 (Gel-CDH) 和二甲基粉 (DS) 之间构建了水凝 (DS/Gel-CDH).
- 通过机械测试评估粘合强度,将其与商业蛋白质粘合剂进行比较.
- 进行了体外细胞毒性 (细胞存活率) 和血液溶解试验.
- 在使用老鼠皮肤切口伤口模型评估体内性能,包括组织学分析 (H&E,MT染色) 和炎症标志物评估 (IL-6,IL-1β).
主要成果:
- DS/Gel-CDH水凝的粘合强度 (34.92 kPa) 比商业蛋白质粘合剂 (17.44 kPa) 高得多.
- 在体外试验证实了水凝的非细胞毒性 (96.9%的细胞存活率) 和血红相容性.
- 在体内研究表明有效的伤口粘附,促进愈合,没有局部毒性或炎症的迹象.
- 组织学和炎症标记分析证实了体内良好的生物相容性和生物降解性.
结论:
- 多功能DS/Gel-CDH水凝具有出色的自我愈合,注射和粘合性能.
- 与现有的基于蛋白质的粘合剂相比,水凝表现出优越的粘附性和生物相容性.
- DS/Gel-CDH水凝是用于组织粘附和伤口愈合的有希望和有效的生物材料.
相关概念视频
Cohesion
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...
On a surface,...
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.Synthesis of carbohydratesSugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from one reactant...


