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Updated: Jun 4, 2025

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
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百脚毒素SsTx-4在内向整形通道上的孔隙阻塞机制

Dongfang Tang1, Jiahui Xu2, Wenhu Bao3

  • 1Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, China; The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of life Sciences, Hunan Normal University, Changsha, China.

European journal of pharmacology
|December 20, 2024
PubMed
概括

千足毒素SsTx-4阻断了内向整整的 (Kir) 通道. 氨酸13 (K13) 是毛孔堵塞的关键残留物,其他残留物稳定了相互作用.

关键词:
行动机制 行动机制基尔频道是基尔的频道.孔阻塞剂 孔阻塞剂在SsTx-4中使用.

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