耐力训练通过促进MOTS-c分泌来增强骨肌肉的线粒体呼吸
Yiwei Feng1, Zhijian Rao2, Xu Tian1
1School of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China.
Free radical biology & medicine
|December 20, 2024
概括
线粒体衍生MOTS-c (12S rRNA-c的线粒体开放读取框架) 的水平与有氧运动能力相关. 耐力训练可以通过MOTS-c和AMPK/PGC-1α通路改善骨肌肉的线粒体功能.
科学领域:
- 运动生理学 运动生理学
- 线粒体生物学 线粒体生物学
- 代谢调节 代谢调节 代谢调节
背景情况:
- 12S rRNA-c (MOTS-c) 的线粒体开放读取框架是一种线粒体衍生的,具有已知的生物活性.
- MOTS-c在骨肌肉线粒体功能和适应耐力运动中的特定作用仍然在很大程度上未被探索.
研究的目的:
- 研究血清MOTS-c水平与人类和小鼠的有氧运动能力之间的关联.
- 探索耐力训练对骨肌肉线粒体呼吸和MOTS-c水平的影响.
- 阐明耐力运动影响线粒体功能的潜在机制,重点关注MOTS-c和AMPK/PGC-1α通路.
主要方法:
- 横截面研究比较马拉松跑者和久坐的人,测量最大氧气摄入量和血清MOTS-c水平.
- 长期耐力训练干预小鼠,评估有氧运动能力,骨肌肉线粒体呼吸率和血清MOTS-c水平.
- 分析AMPK/PGC-1α信号通路对耐力训练的反应.
主要成果:
- 在人类和小鼠模型中,在血清MOTS-c水平和有氧运动能力之间观察到显著的正相关性.
- 耐力训练增强了骨肌肉线粒体呼吸率.
- 耐力训练与循环MOTS-c水平的增加和AMPK/PGC-1α通路的激活有关.
结论:
- 循环MOTS-c水平作为有氧运动能力,身体脂肪状况,训练负载和身体功能的潜在生物标志物.
- 耐力运动可以通过刺激MOTS-c分泌和激活AMPK/PGC-1α通路来改善骨肌肉线粒体呼吸功能.
- MOTS-c代表了一种用于增强线粒体功能和运动表现的新型治疗点.
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