侵入性状细胞癌的瘤结局,通过警等待管理的临床解决的活检部位:一个回顾性队列研究
Blake Boudreaux1, Hayden Christensen2, Hannah J Porter1
1Division of Dermatology, University of Vermont Medical Center, Burlington, Vermont.
Journal of the American Academy of Dermatology
|December 20, 2024
概括
皮肤状细胞癌 (cSCC) 的警等待 (WW),在活检显示出低复发率后似乎得到解决. 免疫功能低下的患者和风湿病患者面临更高的复发风险.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 皮肤状细胞癌 (cSCC) 通常通过外科切除进行治疗.
- 有限的数据存在于cSCC的瘤结局,在显着的解剖后,经过警等待 (WW) 管理cSCC.
研究的目的:
- 为了评估cSCC患者的瘤结局,在观察到临床解决后,由WW管理cSCC患者的癌症结局.
主要方法:
- 病理证明的cSCC病例 (2013-2023) 的回顾性队列研究.
- 纳入标准:记录的临床分辨率>4周的活检后,WW管理,和≥12个月的随访.
主要成果:
- 在WW管理的148种瘤中,有2种 (1.35%) 经历了局部复发.
- 报告没有发生结节转移,远程转移或疾病特异性死亡病例.
- 更高的复发风险与免疫受损状态 (HR=12.87,P=.0193) 和类风湿病 (HR=16.18,P=.0075) 相关.
结论:
- 与手术管理相比,在这个队列中,WW-管理的cSCC的复发率是有利的.
- 对于精选的,低风险的cSCC病变而言,WW可能是一个可行的选择,这些病变在活检后似乎在临床上得到解决.
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