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使用自动化,自我调整的延迟折扣程序评估冲动性

Madison R Carr¹, Yvar van Mourik¹, Paula Gómez-Sotres¹

¹Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, location VU Medical Center, Amsterdam, The Netherlands.

Behavioural brain research

|December 20, 2024

概括

这项研究引入了对动物的自动延迟折扣任务,使得研究冲动性的有效数据收集成为可能. 自动化系统显示出对认知控制和相关障碍的高通量研究的承诺.

科学领域:

神经科学是一个神经科学.
行为科学行为科学

背景情况:

推迟折扣模型认知控制和冲动性.
传统方法需要广泛的培训和实验者的监督.

研究的目的:

适应和验证在动物的自动化CombiCage设置中自调节的延迟折扣程序.
评估培训参数和药理学剂对延迟折扣行为的影响.

主要方法:

在CombiCage中开发了一个自动自调节的延迟折扣任务.
在活动阶段训练动物,收集奖励偏好和调整后延迟的数据.
用安非他胺和SCH23390来评估药理效应.

主要成果:

动物在两周内表现出折扣行为,在七周内表现稳定.
较低的连续选择标准 (ccc) 提高了任务参与和会议效率.
胺改变了奖励偏好和平均调整后延,而SCH23390没有显著的影响.

结论:

自动化程序促进了高通量延迟贴现数据的获取.
这种方法有可能用于寿命冲动性研究,但可能需要对某些药理学研究进行调整.

关键词:

氨基胺是一种安非他命.动物模型动物模型自动化自动化自动化延迟贴现延迟贴现在家的子里冲动性是一种冲动性.自己调整的自我调整.

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