贝塔细胞,但不是自主神经系统,功能与葡萄糖不耐受症早期的MAFLD有关
Rumyana Dimova1, Nevena Chakarova2, Mina Serdarova2
1Department of Endocrinology, Medical University-Sofia, Sofia, Bulgaria dr.roumyana.dimova@gmail.com.
BMJ open diabetes research & care
|December 20, 2024
概括
与代谢相关的脂肪肝疾病 (MAFLD) 与高胰岛素水平有关,而不是对人体有正常或受损的葡萄糖耐受性. 这表明,高胰岛素血症会增加高风险人群中MAFLD的风险.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 以前的研究表明,β细胞和自主功能与代谢相关脂肪肝疾病 (MAFLD) 之间存在联系.
- 本研究研究了控制减弱参数 (CAP) 和胰岛素分泌/作用以及正常葡萄糖耐受性 (NGT) 和受损葡萄糖耐受性 (IGT) 个体的自主活性之间的关系.
研究的目的:
- 探索CAP - - MAFLD的标志物 - - 与胰岛素分泌,胰岛素作用和自主神经系统活动之间的关联.
- 确定在NGT和IGT种群中对MAFLD的交感和副交感活动的作用.
主要方法:
- 25名NGT和27名IGT受试者接受了口服葡萄糖耐受性测试 (OGTT) 和混合食耐受性测试 (MMTT),以评估葡萄糖和胰岛素的动态.
- 使用ANX V.3.0监测系统测量自主功能,使用Fibroscan通过CAP值>233dB/m识别MAFLD.
- 还评估了身体组成和胰岛素敏感度参数.
主要成果:
- MAFLD (CAP>233 dB/m) 在72%的NGT和67%的IGT受试者中流行.
- 患有MAFLD的个体表现出更高的BMI,更低的胰岛素分泌和作用,以及降低的副交感活动,无论葡萄糖耐受性如何.
- 回归分析表明,刺激胰岛素分泌 (AUC-胰岛素MMTT) 与MAFLD独立相关 (OR 24.4,p=0.010).
结论:
- 副交感活动似乎在MAFLD中没有发挥重要作用.
- 在没有糖尿病的高风险人群中,刺激性高胰岛素血症与MAFLD风险增加有关,这与高风险人群的葡萄糖耐受性状况无关.
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