内源性激素和多部位慢性肌肉骨疼痛之间的关联
Zemene Demelash Kifle1, Jing Tian1, Dawn Aitken1
1Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
British journal of anaesthesia
|December 20, 2024
概括
较高的丸激素水平与男性和女性的慢性肌肉骨疼痛部位的减少有关. 性激素结合球蛋白也显示出保护作用,特别是在部/肩部疼痛方面.
科学领域:
- 内分泌学 在内分泌学.
- 疼痛医学 医学 疼痛医学
- 遗传学 是一个遗传学.
背景情况:
- 疼痛感知中的性别差异已经确立,但性激素对慢性肌肉骨疼痛 (CMP) 的影响尚不清楚.
- 研究性激素,性激素结合球蛋白 (SHBG) 和CMP之间的关联对于理解疼痛机制至关重要.
研究的目的:
- 确定 (T),雌激醇 (E2) 和SHBG的血清度之间的关系以及CMP位点的流行率和数量.
- 探索这些激素对慢性疼痛的潜在性别特异性影响.
主要方法:
- 利用了来自357424名参与者的英国生物库数据,测量了血清E2,T和SHBG.
- 通过基线和后续评估,通过多个身体部位评估慢性疼痛 (≥3个月).
- 采用混合效应的多项式/逻辑回归模型进行全面分析.
主要成果:
- 高 (T) 和T/SHBG比率与男性和女性中CMP部位数量的减少有关.
- 较高的T度和T/SHBG比率与所有地点中CMP的几率较低相关.
- 增加的SHBG水平与减少两性部/肩部CMP的几率有关.
结论:
- 较高的T度和T/SHBG比率与较低的慢性肌肉骨疼痛负担有关.
- SHBG可能在减轻部/肩部疼痛方面发挥作用.
- 这些发现突显了性类固醇在CMP病变发生中的潜在作用,并为未来的疼痛管理策略提供了途径.
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