2019年至2023年期间,英国初级和二级保健中诺处方的趋势
Fergus Hamilton1,2, Elizabeth Darley2, Karon Arnold3
1MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
The Journal of antimicrobial chemotherapy
|December 20, 2024
概括
在英格兰的初级保健中,从2019年到2023年,诺基诺抗生素处方每年减少4.2%,这与监管机构关于没有变化的说法相矛盾. 尽管总体抗生素使用稳定,但这种减少发生了,这表明对安全警告的反应是积极的.
科学领域:
- 药物监督 药物监督 药物监督
- 抗生素管理局 抗生素管理局
- 公共卫生政策 公共卫生政策
背景情况:
- 诺基诺,强效的抗生素,携带不良结果的风险.
- 英国药品和卫生监管局 (MHRA) 于2024年1月限制了诺的使用,原因是持续的处方.
- 之前在2019年和2023年的指南未能改变基诺的处方趋势.
研究的目的:
- 分析2019年至2023年期间英格兰诺基诺处方的趋势.
- 评估MHRA指南对诺基诺处方模式的影响.
- 为了比较诺基诺的处方变化与其他抗菌剂.
主要方法:
- 利用了来自英格兰 (2019-2023) 的全国初级和中等保健处方数据.
- 采用线性回归来计算诺基诺物品分发的年度百分比变化.
- 分析了医院住院数据以及处方趋势.
主要成果:
- 在初级保健中,诺基诺分发量每年显著减少4.2% (P < 10−13).
- 这种下降是独立于整体抗菌药物处方量或比较抗生素趋势的.
- 二级护理显示,诺基诺的处方稳定,但相对于比较抗生素使用的上升,相对下降.
结论:
- 在英语初级保健 (2019-2023) 和二级保健 (绝对值) 中,诺基诺的处方明显减少.
- 这些发现挑战了MHRA关于"没有变化"在安全警告后的处方的断言.
- 该研究表明,与MHRA的说法相反,处方做法已经响应了监管方面的担忧.
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