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Updated: Jun 4, 2025

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

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RNA结合蛋白 hnRNPM 和 ELAVL1 促进核酸传感器cGAS 和 RIG-I 下游的 I 型干扰素诱导

Alexander Kirchhoff1, Anna-Maria Herzner2,3, Christian Urban4

  • 1Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany. alkirchhoff@web.de.

The EMBO journal
|December 20, 2024
PubMed
概括

研究人员发现了 hnRNPM 和 ELAVL1 桥梁关键的抗病毒途径,增强了 I 型干扰素反应. 这种RNA结合蛋白质复合体为自身免疫I型干扰性疾病提供了潜在的治疗点.

关键词:
在 ELAVL1 中.在 IRF3 中,IRF3 包含了 IRF3 和 IRF3.在RIG-I信号传输中.cGAS 信号传输 信号传输在 hnRNPMPM 中.

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