通过尿道切除前列腺 (TUR-P) 和相关的感染性内心炎的风险
Emil Loldrup Fosbøl1,2, Anna Stahl3, Andreas Røder4
1The Heart Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. emil.fosboel@regionh.dk.
Infection
|December 20, 2024
概括
经尿道切除前列腺 (TUR-P) 手术显著增加感染性内心炎 (IE) 的风险在六个月内. 虽然绝对风险仍然很低,但这一发现凸显了改善预防策略的必要性,以防止TUR-P之后的IE.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 细菌病是已知的手术并发症,可能导致感染性内心炎 (IE).
- 通过尿道切除前列腺 (TUR-P) 可能导致细菌病,但其对IE的特定风险尚未确立.
- 了解TUR-P后的IE风险对于患者管理和预防措施至关重要.
研究的目的:
- 调查经过过尿道切除前列腺 (TUR-P) 后患有感染性内心炎 (IE) 的风险.
- 将 TUR-P 患者的 IE 发病率与一般人群中年龄匹配的对照组进行比较.
主要方法:
- 一项队列研究比较了2010年至2020年期间接受TUR-P的25781名患者与年龄相匹配的对照组.
- 患者在TUR-P后6个月内和6-12个月内监测IE的发展.
- 统计分析涉及累积发病率和时间依赖的考克斯回归模型.
主要成果:
- 与背景人群相比,TUR-P后6个月内IE的发病率明显高 (调整后的HR 8.16).
- 在IE病例中发现的最常见的病原体是Enterococcus faecalis (72.7%).
- 对于IE的高风险在TUR-P后6-12个月内减少 (调整后的HR 2.15).
结论:
- 经尿道切除前列腺 (TUR-P) 与手术后6个月内感染性内心炎 (IE) 的风险增加了8倍.
- 尽管绝对风险低,但TUR-P是IE的重要风险因素.
- 需要进一步研究 TUR-P 后IE 的增强预防干预措施.
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