美国慢性病成年人中,甘油三指数与心血管疾病之间的关联:基于人口的研究
Lijia Liu1,2, Hui Sun1,2, Lan Yi1
1Department of Nephrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
BMC cardiovascular disorders
|December 20, 2024
概括
甘油三糖 (TyG) 指数与慢性病 (CKD) 患者心血管疾病 (CVD) 的风险更高有关. 这种在晚期CKD阶段特别明显的关联表明,TyG指数对心血管疾病风险评估具有实用性.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 甘油三糖 (TyG) 指数是胰岛素抵抗的公认标志物,并且已显示出对心血管疾病 (CVD) 的预测价值.
- 慢性病 (CKD) 患者的TyG指数和心血管疾病之间的关系仍未得到充分研究.
- 了解这种关联对于在CKD患者中管理心血管疾病风险至关重要.
研究的目的:
- 调查TyG指数与美国CKD患者心血管疾病患病率之间的关联.
- 探索TyG指数对CKD患者心血管疾病的潜在非线性关系和值效应.
- 检查CKD阶段等因素如何改变TyG指数和CVD之间的关系.
主要方法:
- 利用了来自3507名参与国家健康和营养检查调查 (2003-2018) 患有CKD的参与者的数据.
- 采用多变量逻辑回归和平滑曲线拟合来分析TyG指数-CVD关联.
- 进行了子组和相互作用分析,以评估CKD阶段和其他因素的调节作用.
主要成果:
- 在CKD人群中,TyG指数和心血管疾病之间发现了显著,独立和积极的关联 (OR 1.213).
- 在TyG指数8.98.8时,观察到与值效应的非线性关系.
- 这种关联在慢性脏病晚期较强 (或4-5期为2.131),在冠状动脉心脏病 (CHD) 中显著.
结论:
- 泰格指数与CKD患者的心血管疾病风险有关,特别是那些EGFR<60mL/min/1.73m2的患者.
- 存在值效应,突出特定的TyG指数值引起关注.
- 泰格指数显示了作为CKD人口中心血管疾病查和风险评估工具的潜力.
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