血管细胞粘附分子1 在心房动中
ZhiZhi Jiang1, YaZhou Lin1, Hang Ding1
1Shengli Clinical Medical College of Fujian Medical University, No. 134, East Street, Gulou District, Fuzhou, Fujian, 350000, China.
BMC cardiovascular disorders
|December 20, 2024
概括
动脉动 (AF) 患者的血管细胞粘附分子1 (VCAM-1) 水平与中风风险有关. 在左心房附属体和外围静脉中升高的VCAM-1预测了AF相关的中风.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 预防中风 预防中风
背景情况:
- 心房动 (AF) 构成中风的重大风险.
- 确定AF相关中风的可靠生物标志物对于风险分层和预防至关重要.
研究的目的:
- 为了研究血清血管细胞粘附分子1 (VCAM-1) 度在左心房附属体 (LAA) 和外围静脉 (PV) 和AF患者中风风险之间的关联.
- 评估LAA组织中的VCAM-1表达是否与AF中风风险相关.
主要方法:
- 使用ELISA测量了LAA和PV的AF患者的VCAM-1血清水平.
- 在LAA组织中量化了VCAM-1表达,使用免疫组织化学.
- 使用统计分析,包括单变量和多变量逻辑回归来确定预测值.
主要成果:
- 在患有中风的AF患者中,与没有中风的患者相比,在LAA和PV中观察到较高的血清VCAM-1度.
- 在AF中风患者的LAA组织中发现了增加的VCAM-1表达.
- 多变量分析确定LAA血清VCAM-1 (>387.93ppg/ml) 和PVVCAM-1 (>344.04ppg/ml) 作为AF相关中风的显著预测因素.
结论:
- 血清VCAM-1水平和LAA组织表达与AF患者中风风险有关.
- VCAM-1可以作为一个有价值的生物标志物来预测AF相关的中风.
- 对LAA和PV VCAM-1度的特定值可以表明AF中风风险增加.
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