对心力衰竭患者的离子间隙的预后值:系统性审查和元分析
Amirsaeed Samavarchitehrani1, Mitra Norouzi2, Amirmohammad Khalaji3
1Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
BMC cardiovascular disorders
|December 20, 2024
概括
较高的离子间隙 (AG) 水平与心力衰竭 (HF) 患者的死亡率增加有关. 这种易于测量的标志物可能有助于临床风险评估和HF患者管理.
科学领域:
- 心脏病学 心脏病学
- 临床化学 临床化学
- 医学预测 医学预测
背景情况:
- 心力衰竭 (HF) 是一个重大的全球健康挑战,患病率和死亡率很高.
- 识别可访问的预后因素对于有效的高频管理至关重要.
- 之前的研究表明,离子间隙 (AG) 和高频预后之间存在潜在的相关性.
研究的目的:
- 系统地审查和对现有研究进行元分析.
- 评估离子间隙 (AG) 和心力衰竭 (HF) 预后之间的关联.
- 为了确定AG是否可以作为HF患者的预后指标.
主要方法:
- 在PubMed,Embase,Scopus和Web of Science中进行全面的文献搜索.
- 包括九项研究进行系统审查和元分析.
- 使用随机效应模型计算标准化平均差异 (SMD) 和聚合危险比率 (HR).
主要成果:
- 与幸存者相比,非幸存者表现出明显更高的AG水平 (SMD0.57;P < 0.0001).
- 高水平的AG与显著增加的死亡风险相关 (HR 1.64;P < 0.0001).
- 在HF患者中,AG和重症监护室 (ICU) 停留时间之间没有发现显著的关联.
结论:
- 升高的AG水平是心力衰竭患者死亡率的重要预测因素.
- 测量的简单性使得AG成为临床风险分层的潜在有价值工具.
- 需要进一步的研究来证实AG在常规HF患者管理中的实用性.
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