在乌干达的耐药结核病患者中,治疗延迟的预测因素
Nabukenya Diana Kasozi1, Lwanga Charles2, Asiimwe JohnBosco3
1Department of Statistical Methods & Actuarial Sciences, School of Statistics and Planning, College of Business & Management Sciences, Makerere University, Kampala, Uganda. diananabukenya20@gmail.com.
BMC infectious diseases
|December 20, 2024
概括
抗药结核病 (DR-TB) 治疗延迟在乌干达很常见,超过一半的患者经历了延迟. 被诊断为耐利芬素结核病 (RR-TB) 的患者和有复发性结核病史的患者面临更长的治疗开始等待时间.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 耐药结核病 (DR-TB) 仍然是一个关键的全球卫生挑战.
- 对DR-TB的延迟开始治疗加剧了发病率,耐药性和传播.
- 了解治疗延迟对于改善乌干达患者的治疗结果至关重要.
研究的目的:
- 调查乌干达DR-TB患者治疗延迟的程度.
- 确定与延迟开启DR-TB治疗相关的关键预测因素.
主要方法:
- 对国家DR-TB病例登记数据 (2012-2019) 的回顾性分析.
- 统计分析包括单变量,双变量和逻辑回归模型.
- 使用调整的几率比率 (AOR) 确定与DR-TB治疗延迟相关的因素.
主要成果:
- 总共分析了2,166名DR-TB患者,治疗延迟的中位数为10天.
- 57%的患者经历了超过推的7天时间框架的延迟.
- 里芬辛耐药结核病 (RR-TB) 诊断和复发性结核病史是延迟的重要预测因素.
结论:
- 在乌干达的DR-TB患者中发生了显著的治疗延迟.
- 需要对RR-TB和先前接受治疗的结核病患者提高警,以尽量减少延迟.
- 建议对影响治疗开始时间的因素进行进一步研究,以优化干预措施.
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